MTHFR Gene Mutation Protocol
This protocol is designed to support the body’s ability to properly carry out the process of methylation. Methylation is one of the ways that the body makes sure the right genes are turned on, and the ones that we don’t want get turned off. It means that even if we have a gene that predisposes us to a disease like Alzheimer’s, we can help that gene to stay silent by supporting healthy methylation.
“If you already know what MTHFR is, perhaps you know that you have a variant of this gene such as C677T or A1298C. If you have two copies of the C677T gene (this means you are homozygous for this variant) then the MTHFR enzyme’s activity can drop by 70-75%. If you have one copy of this gene (heterozygote) then activity can be reduced by 33-35%. If you have two copies of the A1298C variant you may lose 39% of MTHFR activity. Methylation – What’s All the Fuss? – Kara Fitzgerald ND
But the presence of the MTHFR gene variant in your genetic structure does not mean that the variant has to express itself.
Your body has methods of turning off bad genes as much as it has the ability to stimulate the expression of good genes. This turning on and turning off of jeans is controlled primarily through environmental factors, the most important one being nutrition and food choices.
Methionine is essential for the synthesis of proteins and many other biomolecules required for survival. Rats fed a diet without methionine develop fatty liver disease which was show to be corrected by methionine supplements: [DIGESTIVE DISEASES AND SCIENCES; Oz,HS; 53(3):767-776 (2008)]. Since methylation is dependant on essential amino acids that you can only get from your diet, dietary methionine is essential for DNA methylation. Reduced DNA methylation results in genetic instability and aberrant gene expression.
Natural variation in this gene is common in healthy people. Remember, genes only express themselves when they get a chemical signal to do so. Just as genes can be harmed by outside influences, such as radiation and toxic chemicals, so can gene expression be helped by outside influences as well, the major one being nutritional status.
Supporting healthy methylation is actually a good anti-aging strategy, since we tend to lose methylation capacity as we age, since we do not eat the foods our great-grandparents ate so long ago.
Unless we are well versed in the subject, it is easy to misunderstand the vital importance of nutritionally dense foods, not just for our overall nutritional well-being, but for the vital control of our genetic structure especially when it comes to abnormal gene variants. Without a full time cook following you around it can be difficult to get the proper food to support healthy methylation on a regular basis. I mean, who wants to gnaw on a liver organ, really?.
So we have put together a protocol that supports your body’s need to have healthy gene expression, replication, and to even help your body’s inner intelligence to know when to put the gene variant (mutation) back to sleep.